Gluck had his first film lead role playing Rafe Khatchadorian in the 2016 movie Middle School: The Worst Years of My Life, based on the hit novel by James Patterson.

In 2014, Gluck co-starred as Charlie on the Fox series Red Band Society, in which his character, who is in a coma, is the narrator of the show. In March 2015, he was cast in an NBC pilot, Cuckoo, which was not picked for series.

His big break came in 2011, when he played Michael in the film Just Go with It (starring Adam Sandler and Jennifer Aniston), for which he received a Young Artist Award nomination. He was later cast as Mason Warner on Private Practice, and was then upped to series regular on the show. After the series was cancelled, he joined a TV pilot called Back in the Game from 20th Century Fox TV. It was picked to series. The show was canceled in November 2013

Griffin Alexander Gluck (born August 24, 2000) is an American actor. In television, he is notable for his main roles as Charlie in Red Band Society, Mason Warner in Private Practice, and Danny Gannon in Back in the Game. He also co-starred as Sam Ecklund in both seasons of the Netflix mockumentary series American Vandal and plays Gabe in the Netflix series Locke & Key. In film, he portrayed Rafe Khatchadorian in the film Middle School: The Worst Years of My Life and Jack Dunkleman in the Netflix original movie Tall Girl. He also starred as a main character in the Hulu movie Big Time Adolescence.

Gluck was nominated for “Best Performance in a Feature Film – Supporting Young Actor” category at the 33rd Young Artist Awards.